South Africa & Mauritius are an ideal combination and easily arranged with a little planning.
Choosing your itinerary very much depends on the time of year you are travelling - if departing from SEP - MAR, you should look at Cape Town, the Garden Route and a Safari in the Eastern Cape. IF travelling from APR - AUG, then the Indian Ocean side of South Africa is the best choice.
Mauritius is a big island with lots of fantastic accommodation to choose from and you can go off exploring the surrounds, go scuba diving, snorkelling, etc. All Inclusive is always a good option here and I recommend you book good 4* accomm in South Africa and then splurge a bit on Mauritius.
The best advise I can offer you is to plan and book early! Availability is surprisingly difficult to get for 2017, esp. your safari stay if planning this part of your itinerary.
I would be very happy to advise and help you if I may as I know both destinations better than most!
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