Unborn Baby's health... Dilemma

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marriedinmay Posts: 578
Hello, Only 4 weeks and 2 day BFP!! I am sooooooooooooo confused!!! I take alot of strong medication for my Crohns Disease they are not sure of the affects of medication on a pregnancy it is called [b:2qm1l16v]Humira[/b:2qm1l16v] and injection I give myself once a week. About 4 months ago my consulant said that she would keep me on my medication as whats good for you is good for baby. She has now gone on her maternity leave and before we started TTC I went in for another appointment to claify I saw her regisitra. He said that the affects aren't know and that I should think about switching to anothe drug called [b:2qm1l16v]Azathioprine[/b:2qm1l16v] also a drug that lowers your immune system, what I have read this is also not good for pregnancy, caused birth defects! Anyway I had a colonoscopy last week and they said that the bowel looked better than they had expected! I am now thinking about not taking anything for the first 3 months, I spoke to my GP and she said that she thought as my colonoscopy is good I should refrain for any medication in the first three months as it is an important time for development. I have had so many people give me different advice O:| O:| O:| My consultant is a woman with 3 children and I think I trust her opinion, the 2nd one was a guy and my GP is a woman. I don't want to put my baby at risk but if I was to get ill that would be very bad for the baby too! :o( :o( :o(
Diamondz Posts: 2208
Can't really help on this I'm afraid as I have no experience of your illness.. however, I would be trusting the Consultant who should have specialist knowledge of your condition rather than just your GP who will maintain only a basic knowledge.. just my opinion obviously... Hope it all works out for you...
beatingmyselfintoadress Posts: 2387
Hi, I dont know if this will help but I can tell you what I did. I inject with Enbrel twice per week (works the same way as Humira) for rheumatoid arthritis and I used this right up to when I found out I was pregnant. I wasn't sure what to do then and my consultant wasn't making a decision so after a lot of research I decided to stay off the injections for the whole pregnancy. I got lucky because I went into remission (this may happen to you - lots of auto immune conditions go into remission in pregnancy) and I have had a really good pregnancy, I'm actually due today! Only you can make the decision - when I realised I was in remission I knew I had made the right decision but I was also aware that if my symptoms returned during the pregnancy I would have gone back on the injections to protect my baby. I hope this helps, good luck and congratulations!!
marriedinmay Posts: 578
Ah thats so exciting! Bet you can't wait! My problem is that I am in remission at the moment, 2 years ago I had a major operation 1 meter of my bowel removed was in hospital for ages had physo & epidural for 3 days.It has been really bad, if it got that bad whilst pregnany the baby wouldn't have much chance! But on the other hand I don't want to take a medicaton that may harm the baby. Also I have read that it is really common for Crohn's to be ok whilst pregnant and a flare up to occur after birth! I have also been told that I will need a caseran as too risky for a natual birth ;o(
beatingmyselfintoadress Posts: 2387
Yeah, I read too that auto immune diseases flare within 90 days of delivery. I guess you have decide what's best - protecting the baby from meds or protecting him/her from a flare during pregnancy which sounds like it would be harmful. I know it's not an easy decision, you just have to do what you think is best. Best of luck with it!
cavanmum Posts: 211
Hi , Congrats on your pregnancy. This is an extract from the information on Humira on the European medicines Agency website. http://www.emea.europa.eu/humandocs/Hum ... humira.htm I hope this website will be useful. I am surprised your consultant wasn't of more help. Best of luck with the rest of your pregnancy. [b:3o283hfw]4.6 Pregnancy and lactation[/b:3o283hfw] For Humira, no clinical data on exposed pregnancies are available In a developmental toxicity study conducted in monkeys, there was no indication of maternal toxicity, embryotoxicity or teratogenicity. Preclinical data on postnatal toxicity and fertility effects of adalimumab are not available (see section 5.3). Due to its inhibition of TNFα, adalimumab administered during pregnancy could affect normal immune responses in the newborn. Administration of adalimumab is not recommended during pregnancy. Women of childbearing potential are strongly recommended to use adequate contraception to prevent pregnancy and continue its use for at least five months after the last Humira treatment. It is not known whether adalimumab is excreted in human milk or absorbed systemically after ingestion. However, because human immunoglobulins are excreted in milk, women must not breast-feed for at least five months after the last Humira treatment. 5.3 Preclinical safety data Non-clinical data reveal no special hazard for humans based on studies of single dose toxicity, repeated dose toxicity, and genotoxicity. An embryo-foetal developmental toxicity/perinatal developmental study has been performed in cynomologous monkeys at 0, 30 and 100 mg/kg (9-17 monkeys/group) and has revealed no evidence of harm to the foetuses due to adalimumab. Neither carcinogenicity studies, nor a standard assessment of fertility and postnatal toxicity, were performed with adalimumab due to the lack of appropriate models for an antibody with limited cross-reactivity to rodent TNF and to the development of neutralizing antibodies in rodents.
marriedinmay Posts: 578
Hi Hope4ababy! Thats for getting that information, I have trailed through the internet and everywhere I look the advice is different, most places say it is a problem TTC whilst on the medication, although a year ago all the web sites advised against it! Thats why I carried on my injection until finding out I was pregnant. So I think new data is coming through all the time. Strangly enough I found a web site with people that have been prescribed Humira shots to assit fertility! :eek I mean they have been helpful but not if you know what I mean just 2 different sets of advice! O:|